Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Apr 10;157(2):294-299.
doi: 10.1016/j.cell.2014.03.023.

Peering into the crystal ball: influenza pandemics and vaccine efficacy

Matthew S Miller  1 , Peter Palese  2
Affiliations
Free article

Peering into the crystal ball: influenza pandemics and vaccine efficacy

Matthew S Miller et al. Cell. .
Free article

Abstract

The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely needed in order to improve the effectiveness of influenza virus vaccines. Will new studies aimed at identifying adaptations required for virus transmissibility and systems-level analyses of influenza virus vaccine responses provide an improved framework for predictive models of viral adaptation and vaccine efficacy?

PubMed Disclaimer

Similar articles

  • Vaccines for pandemic influenza.
    Luke CJ, Subbarao K. Luke CJ, et al. Emerg Infect Dis. 2006 Jan;12(1):66-72. doi: 10.3201/eid1201.051147. Emerg Infect Dis. 2006. PMID: 16494720 Free PMC article. Review.
  • [Vaccines against highly pathogenic influenza viruses of the avian origin].
    Sergeeva MV, Romanova IuR. Sergeeva MV, et al. Vopr Virusol. 2013 Jul-Aug;58(4):4-9. Vopr Virusol. 2013. PMID: 24354058 Review. Russian.
  • Antigenic and genetic characteristics of zoonotic influenza viruses and development of candidate vaccine viruses for pandemic preparedness.
    [No authors listed] [No authors listed] Wkly Epidemiol Rec. 2012 Mar 16;87(11):97-108. Wkly Epidemiol Rec. 2012. PMID: 22462204 English, French. No abstract available.
  • The development of vaccine viruses against pandemic A(H1N1) influenza.
    Robertson JS, Nicolson C, Harvey R, Johnson R, Major D, Guilfoyle K, Roseby S, Newman R, Collin R, Wallis C, Engelhardt OG, Wood JM, Le J, Manojkumar R, Pokorny BA, Silverman J, Devis R, Bucher D, Verity E, Agius C, Camuglia S, Ong C, Rockman S, Curtis A, Schoofs P, Zoueva O, Xie H, Li X, Lin Z, Ye Z, Chen LM, O'Neill E, Balish A, Lipatov AS, Guo Z, Isakova I, Davis CT, Rivailler P, Gustin KM, Belser JA, Maines TR, Tumpey TM, Xu X, Katz JM, Klimov A, Cox NJ, Donis RO. Robertson JS, et al. Vaccine. 2011 Feb 17;29(9):1836-43. doi: 10.1016/j.vaccine.2010.12.044. Epub 2011 Jan 1. Vaccine. 2011. PMID: 21199698
  • Synthetic generation of influenza vaccine viruses for rapid response to pandemics.
    Dormitzer PR, Suphaphiphat P, Gibson DG, Wentworth DE, Stockwell TB, Algire MA, Alperovich N, Barro M, Brown DM, Craig S, Dattilo BM, Denisova EA, De Souza I, Eickmann M, Dugan VG, Ferrari A, Gomila RC, Han L, Judge C, Mane S, Matrosovich M, Merryman C, Palladino G, Palmer GA, Spencer T, Strecker T, Trusheim H, Uhlendorff J, Wen Y, Yee AC, Zaveri J, Zhou B, Becker S, Donabedian A, Mason PW, Glass JI, Rappuoli R, Venter JC. Dormitzer PR, et al. Sci Transl Med. 2013 May 15;5(185):185ra68. doi: 10.1126/scitranslmed.3006368. Sci Transl Med. 2013. PMID: 23677594
See all similar articles

Cited by

See all "Cited by" articles

Publication types

Substances

LinkOut - more resources