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Review
. 2015 Jul;9(3):257-69.
doi: 10.1111/crj.12135. Epub 2014 May 15.

Inflammation and infections in asthma

Adrian Gillissen  1 , Maria Paparoupa  1
Affiliations
Review

Inflammation and infections in asthma

Adrian Gillissen et al. Clin Respir J. 2015 Jul.

Abstract

Introduction: Asthma is driven by an inflammatory response against normally harmless environmental inorganic and organic compounds in the respiratory tract. Immune responses to airborne pathogens such as viruses and bacteria may reduce the allergic responses but are also known to trigger asthma attacks and eventually lead to severe disease condition.

Objective: To investigate the role of respiratory pathogens concerning the induction or protection against acute or chronic asthma manifestations.

Methods: We included 131 articles for the final review according to their relevance with the subject.

Results: There is apparently contradictory interaction of respiratory germs in the airways of asthmatics which may be protective on one angle but deleterious on the other.

Conclusion: The relationship between inflammation and remodeling and the pathogenic role of viral and bacterial infection in the airways of asthmatic patients is still highly debatable and incompletely understood.

Keywords: asthma; asthma control; bacteria; infection; virus.

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Figures

Figure 1
Figure 1
Chronic inflammation in the airways leads to remodeling in the airways (right side). ECM, extracellular matrix.
See this image and copyright information in PMC

References

    1. GINA Executive and Science Committee , editor. Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention. Bethesda, USA, US Department of Health and Human Services, 2012.
    1. Koziol‐White CJ, Panettieri RA Jr. Airway smooth muscle and immunomodulation in acute exacerbations of airway disease. Immunol Rev. 2011;242: 178–185. - PubMed
    1. Green RH, Brightling CE, McKenna S, Hargadon B, Parker D, Bradding P, Wardlaw AJ, Pavord ID. Asthma exacerbations and sputum eosinophil counts: a randomized controlled trial. Lancet. 2002;360: 1715–1721. - PubMed
    1. Bjermer L. History and future perspectives of treating asthma as a systemic and small airways disease. Respir Med. 2001;95: 703–719. - PubMed
    1. Jeffery PK. Remodelling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1: 176–183. - PubMed

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