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Multicenter Study
. 2014 Jun;14(6):1328-33.
doi: 10.1111/ajt.12691. Epub 2014 Apr 11.

Epidemiology of invasive mold infections in lung transplant recipients

C T Doligalski  1 , K Benedict, A A Cleveland, B Park, G Derado, P G Pappas, J W Baddley, D W Zaas, M T Harris, B D Alexander
Affiliations
Multicenter Study

Epidemiology of invasive mold infections in lung transplant recipients

C T Doligalski et al. Am J Transplant. 2014 Jun.

Abstract

Invasive mold infections (IMIs) are a major source of morbidity and mortality among lung transplant recipients (LTRs), yet information regarding the epidemiology of IMI in this population is limited. From 2001 to 2006, multicenter prospective surveillance for IMIs among LTR was conducted by the Transplant-Associated Infection Surveillance Network. The epidemiology of IMI among all LTRs in the cohort is reported. Twelve percent (143/1173) of LTRs under surveillance at 15 US centers developed IMI infections. The 12-month cumulative incidence of IMIs was 5.5%; 3-month all-cause mortality was 21.7%. Aspergillus caused the majority (72.7%)of IMIs; non-Aspergillus infections (39, 27.3%) included Scedosporium (5, 3.5%), mucormycosis (3, 2.1%) and "unspecified" or "other" mold infections (31, 21.7%). Late-onset IMI was common: 52% occurred within 1 year posttransplant (median 11 months, range 0-162 months). IMIs are common late-onset complications with substantial mortality in LTRs. LTRs should be monitored for late-onset IMIs and prophylactic agents should be optimized based on likely pathogen.

Keywords: Epidemiology; infection; lung transplant; mold.

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Conflict of interest statement

Conflicts of Interest

Christina T. Doligalski: nothing to disclose

Benjamin Park: nothing to disclose

Kaitlin Benedict: nothing to disclose

Angela A. Cleveland: nothing to disclose

Peter G. Pappas:

John W. Baddley:

David W. Zaas: Pfizer, APT Pharmaceuticals, and Merck

Matthew T. Harris: nothing to disclose

Barbara D. Alexander: Research grants from Astellas, Pfizer, Charles River Laboratores; Advisor for Bristol Myers Squibb, bioMerieux, Astellas

Figures

Figure 1
Figure 1
Infecting mold pathogens in 143 episodes of invasive mold infections occurring in lung transplant recipients.
Figure 2
Figure 2
Twelve month cumulative incidence by type of first invasive mold infection (top line invasive aspergillosis; bottom line non-aspergillosis invasive mold infection).
Figure 3
Figure 3
Frequency of invasive mold infection diagnosis by months post-transplant (n=143)
See this image and copyright information in PMC

References

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