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. 2014 May 1;24(9):2057-61.
doi: 10.1016/j.bmcl.2014.03.063. Epub 2014 Mar 28.

Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors

Michael P Winters  1 , Nalin Subasinghe  2 , Mark Wall  2 , Edward Beck  2 , Michael R Brandt  2 , Michael F A Finley  2 , Yi Liu  2 , Mary Lou Lubin  2 , Michael P Neeper  2 , Ning Qin  2 , Christopher M Flores  2 , Zhihua Sui  2
Affiliations

Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors

Michael P Winters et al. Bioorg Med Chem Lett. .

Abstract

A novel series of substituted 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles were investigated as N-type calcium channel blockers (Cav2.2 channels), a chronic pain target. One compound was active in vivo in the rat CFA pain model.

Keywords: 2,4,5,6-Tetrahydrocyclopenta[c]pyrazoles; Ca(v)2.2 blockers; N-type calcium channel; Pain; Rat CFA model.

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