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Review
. 2014 Jul;31(100):20-9.
doi: 10.1016/j.semcdb.2014.04.011. Epub 2014 Apr 13.

The role of the cytoskeleton and molecular motors in endosomal dynamics

Elizabeth Granger  1 , Gavin McNee  1 , Victoria Allan  2 , Philip Woodman  3
Affiliations
Review

The role of the cytoskeleton and molecular motors in endosomal dynamics

Elizabeth Granger et al. Semin Cell Dev Biol. 2014 Jul.

Abstract

The endocytic pathway is essential for processes that define how cells interact with their environment, including receptor signalling, cell adhesion and migration, pathogen entry, membrane protein turnover and nutrient uptake. The spatial organisation of endocytic trafficking requires motor proteins that tether membranes or transport them along the actin and microtubule cytoskeletons. Microtubules, actin filaments and motor proteins also provide force to deform and assist in the scission of membranes, thereby facilitating endosomal sorting and the generation of transport intermediates.

Keywords: Dynein; Endosome; Kinesin; Lysosome; Myosin; Recycling.

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Figures

Fig. 1
Fig. 1
Overview of the endocytic pathway and the cytoskeleton. Transport steps are shown using solid arrows, maturation steps are shown using broken arrows.
Fig. 2
Fig. 2
Molecular composition of dynein (A) and dynactin (B). The AAA ATPase subunits (1–6) and C-terminal domain (C) of dynein heavy chain (blue) are labelled.
See this image and copyright information in PMC

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