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Review
. 2014 Apr 1;5(2):126-36.
doi: 10.14336/AD.2014.0500126. eCollection 2014 Apr.

Sepsis in old age: review of human and animal studies

Marlene E Starr  1 , Hiroshi Saito  2
Affiliations
Review

Sepsis in old age: review of human and animal studies

Marlene E Starr et al. Aging Dis. .

Abstract

Sepsis is a serious problem among the geriatric population as its incidence and mortality rates dramatically increase with advanced age. Despite a large number of ongoing clinical and basic research studies, there is currently no effective therapeutic strategy that rescues elderly patients with severe sepsis. Recognition of this problem is relatively low as compared to other age-associated diseases. The disparity between clinical and basic studies is a problem, and this is likely due, in part, to the fact that most laboratory animals used for sepsis research are not old while the majority of sepsis cases occur in the geriatric population. The objective of this article is to review recent epidemiological studies and clinical observations, and compare these with findings from basic laboratory studies which have used aged animals in experimental sepsis.

Keywords: aging; animal models; coagulation; elderly; inflammation; sepsis.

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References

    1. Podnos YD, Jimenez JC, Wilson SE. Intra-abdominal Sepsis in Elderly Persons. Clin Infect Dis. 2002;35:62–68. - PubMed
    1. Kale SS, Yende S. Effects of Aging on Inflammation and Hemostasis through the Continuum of Critical Illness. Aging Dis. 2011;2:501–511. - PMC - PubMed
    1. Opal SM, Girard TD, Ely EW. The immunopathogenesis of sepsis in elderly patients. Clin Infect Dis. 2005;41(Suppl 7):S504–512. - PubMed
    1. Pisani MA. Considerations in caring for the critically ill older patient. J Intensive Care Med. 2009;24:83–95. - PubMed
    1. Wier M, Andrews RM. HCUP, editor. The National Hospital Bill: The Most Expensive Conditions by Payer, 2008. 2011. Vol. Statistical Brief #107. - PubMed