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Review
. 2014:2014:503634.
doi: 10.1155/2014/503634. Epub 2014 Mar 4.

Noncoding RNAs: emerging players in muscular dystrophies

Germana Falcone  1 , Alessandra Perfetti  2 , Beatrice Cardinali  1 , Fabio Martelli  2
Affiliations
Review

Noncoding RNAs: emerging players in muscular dystrophies

Germana Falcone et al. Biomed Res Int. 2014.

Abstract

The fascinating world of noncoding RNAs has recently come to light, thanks to the development of powerful sequencing technologies, revealing a variety of RNA molecules playing important regulatory functions in most, if not all, cellular processes. Many noncoding RNAs have been implicated in regulatory networks that are determinant for skeletal muscle differentiation and disease. In this review, we outline the noncoding RNAs involved in physiological mechanisms of myogenesis and those that appear dysregulated in muscle dystrophies, also discussing their potential use as disease biomarkers and therapeutic targets.

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Figures

Figure 1
Figure 1
Biogenesis and mechanisms of action of miRNAs (a) and lncRNAs (b).
Figure 2
Figure 2
Regulation of the myogenic differentiation program by myomiRs and lncRNAs.
Figure 3
Figure 3
Linc-MD1 regulation of myogenic differentiation.
Figure 4
Figure 4
Therapeutic strategies targeting miRNAs.
See this image and copyright information in PMC

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