Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1989 Aug;57(8):2272-8.
doi: 10.1128/iai.57.8.2272-2278.1989.

Receptor-mediated adherence of Campylobacter pylori to mouse Y-1 adrenal cell monolayers

D G Evans  1 , D J Evans Jr, D Y Graham
Affiliations

Receptor-mediated adherence of Campylobacter pylori to mouse Y-1 adrenal cell monolayers

D G Evans et al. Infect Immun. 1989 Aug.

Abstract

An in vitro adherence assay was developed to study the adherence of Campylobacter pylori to mammalian cells. Strains of C. pylori were isolated from individuals with gastritis. These strains possessed the fibrillar N-acetylneuraminyllactose(neuraminlactose)-binding hemagglutinin (NLBH) and were found to adhere to monolayers of mouse Y-1 adrenal cells. Adherence was rapid, prevented by pretreatment of the Y-1 cells with Clostridium perfringens neuraminidase, and blocked by the neuraminlactose-containing protein fetuin. Electron microscopy by the immunogold technique and with anti-NLBH antibody showed that NLBH was present at the sites of interaction between C. pylori and the Y-1 cells. These results indicate that the Y-1 monolayer is a valid model for receptor-specific adherence of C. pylori.

PubMed Disclaimer

References

    1. Gut. 1986 Jun;27(6):642-7 - PubMed
    1. Scand J Gastroenterol Suppl. 1988;142:93-100 - PubMed
    1. J Clin Pathol. 1986 Aug;39(8):863-70 - PubMed
    1. J Clin Microbiol. 1986 Nov;24(5):716-20 - PubMed
    1. Am J Gastroenterol. 1987 Apr;82(4):283-6 - PubMed

Publication types

LinkOut - more resources