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. 2014 Oct;22(10):957-60.
doi: 10.1016/j.jagp.2014.03.008. Epub 2014 Mar 21.

Association of apolipoprotein E-e4 and dementia declines with age

Daniel Valerio  1 , Henriette Raventos  2 , James Schmeidler  3 , Michal S Beeri  4 , Lara Mora Villalobos  5 , Patricia Bolaños-Palmieri  5 , José R Carrión-Baralt  6 , Jaime Fornaguera  7 , Jeremy M Silverman  8
Affiliations

Association of apolipoprotein E-e4 and dementia declines with age

Daniel Valerio et al. Am J Geriatr Psychiatry. 2014 Oct.

Abstract

Objective: To study the association of dementia with apolipoprotein E-e4 (APOE-e4) and its interaction with age in a nonagenarian Costa Rican group (N-sample) and a general elderly contrast group (GE-sample).

Methods: In both case-control studies, participants were cognitively intact or diagnosed with dementia. The N-sample (N = 112) was at least age 90 years; the GE-sample (N = 98) was at least age 65 years.

Results: Dementia and APOE-e4 were not significantly associated in the N-sample, but were in the GE-sample. There was a significant interaction of age with APOE-e4 in the N-sample, but not in the GE-sample. Descriptively dividing the N-sample at the median (age 93 years) showed a group interaction: APOE-e4 was more associated with dementia in the younger N-sample than in the older N-sample, where six of seven APOE-e4 carriers were cognitively intact.

Conclusions: The results support the reduction in association of APOE-e4 with dementia in extreme old age, consistent with a survivor effect model for successful cognitive aging.

Keywords: Successful cognitive aging; dementia risk factors; oldest-old.

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