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. 2014 Apr 11;19(4):4595-607.
doi: 10.3390/molecules19044595.

In vitro antioxidant and cytotoxic activity of some synthetic riparin-derived compounds

Geandra B L Nunes  1 , Paola R Policarpo  2 , Luciana M Costa  3 , Teresinha G da Silva  4 , Gardenia Carmen G Militão  5 , Celso A Câmara  6 , José Maria Barbosa Filho  7 , Stanley Juan C Gutierrez  8 , Mohammed T Islam  9 , Rivelilson M de Freitas  10
Affiliations

In vitro antioxidant and cytotoxic activity of some synthetic riparin-derived compounds

Geandra B L Nunes et al. Molecules. .

Abstract

This study aimed to study the in vitro antioxidant activity and cytotoxicity on tumor cells lines of six synthetic substances derived from riparins. All the substances showed antioxidant activity and riparins C, D, E, F presented cell growth inhibition rates greater than 70%, suggesting that these molecules have antitumor properties. These substances also caused greater than 80% releases of cytoplasmic lactate dehydrogenase enzyme (LDH). Although the antioxidant and antitumor properties presented herein require further assessment, the outcomes indicate that these novel riparins are promising biologically active compounds.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Scheme 1
Scheme 1
General reaction of synthetic riparins A, B, C, D, E and F.
See this image and copyright information in PMC

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