Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Jun;90(6):984-7.
doi: 10.4269/ajtmh.14-0004. Epub 2014 Apr 14.

Severe neutropenia in dengue patients: prevalence and significance

Tun-Linn Thein  1 , David C Lye  2 , Yee-Sin Leo  2 , Joshua G X Wong  2 , Ying Hao  2 , Annelies Wilder-Smith  2
Affiliations

Severe neutropenia in dengue patients: prevalence and significance

Tun-Linn Thein et al. Am J Trop Med Hyg. 2014 Jun.

Abstract

Studies on severe neutropenia in dengue are scarce, and its clinical significance is uncertain. We analyzed a cohort of 1,921 reverse transcription polymerase chain reaction-confirmed adult dengue patients admitted to the Communicable Disease Center in Singapore between 2005 and 2008. Time trend analyses for daily absolute neutrophil counts (ANCs) were done using Bayesian hierarchical and Markov models. We found that severe neutropenia, defined as ANC ≤ 0.5 × 10(9)/L, was found in 11.8% with a median duration of 1 day. ANC nadir occurred on illness day 5. Severe neutropenia was not predictive of more severe disease and not associated with secondary bacterial infections, prolonged hospital stay, prolonged fever, or fatal outcome. We concluded that prophylactic antibiotics are not indicated in patients with severe neutropenia without indication for bacterial infection.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Time trend of absolute neutrophil count (ANC) for the (A) whole cohort and (B) DHF versus non-DHF. (Overall means are indicated as solid lines, with 95% credible intervals indicated as dashed lines. The red bar on the x axis indicates days with a significant difference between DHF and non-DHF by z test. The blue line indicates an ANC level of 1.5 × 109/L.)
See this image and copyright information in PMC

References

    1. Wilder-Smith A, Schwartz E. Dengue in travelers. N Engl J Med. 2005;353:924–932. - PubMed
    1. Simmons CP, Farrar JJ, Nguyen vV, Wills B. Dengue. N Engl J Med. 2012;366:1423–1432. - PubMed
    1. Ali N, Usman M, Syed N, Khurshid M. Haemorrhagic manifestations and utility of haematological parameters in dengue fever: a tertiary care centre experience at Karachi. Scand J Infect Dis. 2007;39:1025–1028. - PubMed
    1. Wilder-Smith A, Earnest A, Paton NI. Use of simple laboratory features to distinguish the early stage of severe acute respiratory syndrome from dengue fever. Clin Infect Dis. 2004;39:1818–1823. - PMC - PubMed
    1. Chadwick D, Arch B, Wilder-Smith A, Paton N. Distinguishing dengue fever from other infections on the basis of simple clinical and laboratory features: application of logistic regression analysis. J Clin Virol. 2006;35:147–153. - PubMed

Publication types