doi: 10.1097/00005344-198900135-00051.
Molecular mechanism of endothelin-1 action on aortic cells
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- PMID: 2473304
- DOI: 10.1097/00005344-198900135-00051
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Molecular mechanism of endothelin-1 action on aortic cells
J Cardiovasc Pharmacol.
1989.
Abstract
The vasoconstricting action of endothelin-1 (ET-1) is partly mediated by voltage-dependent L-type Ca2+ channels. Activation of the Ca2+ channels is indirect. ET-1 action involves (i) the hydrolysis of phosphatidylinositol and the release of Ca2+ from internal stores and (ii) the opening of a nonselective cation channel in the plasma membrane. The resulting depolarization triggers the activity of L-type Ca2+ channels.
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