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Review
. 2014 Apr;30(2):243-52.
doi: 10.1007/s12264-013-1424-x. Epub 2014 Apr 15.

Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

David J Bonda  1 , Xinglong Wang, Hyoung-Gon Lee, Mark A Smith, George Perry, Xiongwei Zhu
Affiliations
Review

Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

David J Bonda et al. Neurosci Bull. 2014 Apr.

Abstract

Considerable debate and controversy surround the cause(s) of Alzheimer's disease (AD). To date, several theories have gained notoriety, however none is universally accepted. In this review, we provide evidence for the oxidative stress-induced AD cascade that posits aged mitochondria as the critical origin of neurodegeneration in AD.

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