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Editorial
. 2014 May;16(5):615-6.
doi: 10.1093/neuonc/nou041.

Progression-free survival: too much risk, not enough reward?

Brian M Alexander  1 , Lorenzo Trippa
Affiliations
Editorial

Progression-free survival: too much risk, not enough reward?

Brian M Alexander et al. Neuro Oncol. 2014 May.
No abstract available

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References

    1. Han K, Ren M, Wick W, et al. Progression-free survival as a surrogate endpoint for overall survival in glioblastoma: a literature-based meta-analysis from 91 trials. Neuro Oncol. 2014;16:696–706. - PMC - PubMed
    1. Prentice RL. Surrogate endpoints in clinical trials: definition and operational criteria. Stat Med. 1989;8:431–440. - PubMed
    1. Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10:459–466. - PubMed
    1. Broglio KR, Berry DA. Detecting an overall survival benefit that is derived from progression-free survival. J Natl Cancer Inst. 2009;101:1642–1649. - PMC - PubMed
    1. Gilbert MR, Dignam JJ, Armstrong TS, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):699–708. - PMC - PubMed