Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014:2014:767424.
doi: 10.1155/2014/767424. Epub 2014 Mar 10.

An update on coronary artery disease and chronic kidney disease

Baris Afsar  1 , Kultigin Turkmen  2 , Adrian Covic  3 , Mehmet Kanbay  4
Affiliations
Review

An update on coronary artery disease and chronic kidney disease

Baris Afsar et al. Int J Nephrol. 2014.

Abstract

Despite the improvements in diagnostic tools and medical applications, cardiovascular diseases (CVD), especially coronary artery disease (CAD), remain the most common cause of morbidity and mortality in patients with chronic kidney disease (CKD). The main factors for the heightened risk in this population, beside advanced age and a high proportion of diabetes and hypertension, are malnutrition, chronic inflammation, accelerated atherosclerosis, endothelial dysfunction, coronary artery calcification, left ventricular structural and functional abnormalities, and bone mineral disorders. Chronic kidney disease is now recognized as an independent risk factor for CAD. In community-based studies, decreased glomerular filtration rate (GFR) and proteinuria were both found to be independently associated with CAD. This paper will discuss classical and recent epidemiologic, pathophysiologic, and clinical aspects of CAD in CKD patients.

PubMed Disclaimer

References

    1. United States Renal Data System. USRDS 2006 Annual Data Report. Bethesda, Md, USA: National Institute of Diabetes and digestive and Kidney Diseases; 2006. Atlas of end-stage renal disease in United States.
    1. Parfrey PS, Foley RN, Harnett JD, Kent GM, Murray D, Barre PE. Outcome and risk factors of ischemic heart disease in chronic uremia. Kidney International. 1996;49(5):1428–1434. - PubMed
    1. Collins AJ. Cardiovascular mortality in end-stage renal disease. American Journal of the Medical Sciences. 2003;325(4):163–167. - PubMed
    1. Parfrey PS, Foley RN, Harnett JD, Kent GM, Murray DC, Barre PE. Outcome and risk factors for left ventricular disorders in chronic uraemia. Nephrology Dialysis Transplantation. 1996;11(7):1277–1285. - PubMed
    1. Sarnak MJ, Levey AS, Schoolwerth AC, et al. Kidney disease as a risk factor for development of Cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108(17):2154–2169. - PubMed

LinkOut - more resources