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. 2014 Apr 15:14:365.
doi: 10.1186/1471-2458-14-365.

Adherence to antiretroviral therapy and its associated factors among children at South Wollo Zone Hospitals, Northeast Ethiopia: a cross-sectional study

Getachew Arage, Gizachew Assefa Tessema  1 , Hiwot Kassa
Affiliations

Adherence to antiretroviral therapy and its associated factors among children at South Wollo Zone Hospitals, Northeast Ethiopia: a cross-sectional study

Getachew Arage et al. BMC Public Health. .

Abstract

Background: Poor adherence to antiretroviral therapy negatively affects the suppression of viral replication. It increases risks of drug resistance, treatment failure, Acquired Immuno Deficiency Syndrome (AIDS)-related morbidity and mortality among children. This study assessed the level of adherence to antiretroviral therapy and its associated factors among children at hospitals in South Wollo Zone, Northeast Ethiopia.

Methods: An institution-based cross-sectional study was conducted among Human Immunodeficiency Virus (HIV)-infected children in April 2013. A total of 464 children who were taking Antiretroviral Therapy (ART) in the hospitals were included. Data were collected using pretested and structured questionnaires using a face-to-face interview method. Descriptive and summary statistics were employed. Bivariate and multiple logistic regressions were computed. Odds ratios and their 95% confidence intervals were computed to determine the level of significance.

Results: Of the 464 study samples, 440 children with their caregivers were included in the final analysis. A total of 78.6% of the caregivers reported that their children were adherent to antiretroviral therapy in the month prior to the interview. Caregivers' knowledge about antiretroviral treatment [AOR = 2.72(95% CI: 1.82, 5.39)], no current substance use of the caregivers [Adjusted Odds Ratio (AOR) = 2.21(95% Confidence Interval (CI): 1.34, 7.13)], proximity to the health care facility [AOR = 2.31(95% CI: 1.94, 4.63)], if the child knows HIV-positive status [AOR = 3.47(95% CI: 2.10, 6.81)] and caregiver's educational status [AOR = 0.59(95% CI: 0.21, 0.82)] were significantly and independently associated with adherence of children to antiretroviral therapy.

Conclusion: Adherence of antiretroviral therapy in this study was comparable to other studies conducted in developing countries. Caregiver's knowledge about antiretroviral therapy, no current use of substances, close proximity to health facilities, and letting child's know his/her HIV status improves adherence to antiretroviral therapy. Health care providers should educate caregivers about antiretroviral therapy and encourage HIV positive status disclosure to the child.

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Figures

Figure 1
Figure 1
Reasons for non-adherence to ART among children at South Wollo Zone Hospitals, Northeast Ethiopia, 2013.
See this image and copyright information in PMC

References

    1. UNAIDS. “Global report: UNAIDS report on the global AIDS epidemic 2012,” Tech. Rep., United Nations Programme on HIV/AIDS, Geneva, Switzerland, 2012
    1. Federal Ministry of Health, Ethiopia. National Comprehensive PMTCT/NMCH Training Package. Reference Manual. Addis Ababa, Ethiopia. Ethiopia: Federal Ministry of Health; 2011.
    1. Memirie ST. Clinical outcome of children on HAART at police referral hospital, Addis Ababa, Ethiopia. Ethiop Med J. 2009;47(2):159–164. - PubMed
    1. Mea K. Mortality and clinical outcomes in HIV-infected children on antiretroviral therapy in Malawi, Lesotho, and Swaziland. Pediatrics. 2012;130(3):591–599. doi: 10.1542/peds.2011-1187. - DOI - PMC - PubMed
    1. Vreeman RC, Nyandiko WM, Ayaya SO, Walumbe EG, Marrero DG, Inui TS. The perceived impact of disclosure of pediatric HIV status on pediatric antiretroviral therapy adherence, child well-being, and social relationships in a resource-limited setting. AIDS Patient Care STDS. 2010;24(10):639–649. doi: 10.1089/apc.2010.0079. - DOI - PMC - PubMed

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