Protein translocation: the Sec61/SecYEG translocon caught in the act
- PMID: 24735854
- DOI: 10.1016/j.cub.2014.02.051
Protein translocation: the Sec61/SecYEG translocon caught in the act
Abstract
The Sec61/SecYEG complex mediates both the translocation of newly synthesized proteins across the membrane and the integration of transmembrane segments into the lipid bilayer. New cryo-electron microscopy studies show ribosome-channel complexes in action and reveal their repertoire of conformational states.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Comment on
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Structure of the SecY channel during initiation of protein translocation.Nature. 2014 Feb 6;506(7486):102-6. doi: 10.1038/nature12720. Epub 2013 Oct 23. Nature. 2014. PMID: 24153188 Free PMC article.
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Structures of the Sec61 complex engaged in nascent peptide translocation or membrane insertion.Nature. 2014 Feb 6;506(7486):107-10. doi: 10.1038/nature12950. Nature. 2014. PMID: 24499919
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