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Comment
. 2014 Apr 14;25(4):407-8.
doi: 10.1016/j.ccr.2014.03.031.

Genomic dark matter sheds light on EVI1-driven leukemia

Richard P Koche  1 , Scott A Armstrong  2
Affiliations
Comment

Genomic dark matter sheds light on EVI1-driven leukemia

Richard P Koche et al. Cancer Cell. .

Abstract

The orchestration of transcriptional programs depends on proper gene-enhancer pairing. While much remains to be learned about this process in normal development, two recent studies in Cell (Gröschel and colleagues) and this issue of Cancer Cell (Yamazaki and colleagues) highlight how the genomic rearrangement of an enhancer plays a causal role in the onset of a leukemogenic program.

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Figures

Figure 1
Figure 1. A Single Enhancer Rearrangement Deregulates Two Oncogenic Drivers
A. The distal enhancer normally drives GATA2 expression in a myeloid-specific manner. Inversion or translocation of the locus simultaneously results in functional haploinsufficiency of GATA2 and upregulation of EVI1. B. The enhancer can be deactivated through genome editing or pharmacologic BET inhibition. A novel BAC-linking strategy allowed a faithful recapitulation of the rearrangement and disease in a mouse model.
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References

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Plus

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