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Comment
. 2014 Apr 14;25(4):411-3.
doi: 10.1016/j.ccr.2014.03.028.

Harnessing the hidden antitumor power of the MLL-AF4 oncogene to fight leukemia

Smita Matkar  1 , Bryson W Katona  1 , Xianxin Hua  2
Affiliations
Comment

Harnessing the hidden antitumor power of the MLL-AF4 oncogene to fight leukemia

Smita Matkar et al. Cancer Cell. .

Abstract

It is unclear whether the antiproliferative/proapoptotic activity of oncogenes can be pharmacologically reactivated in cancer cells. In this issue of Cancer Cell, Liu and colleagues report that a proteasome inhibitor reactivates an MLL-AF4 controlled antitumor program to kill leukemia cells in an oncogene dose- and cell type-dependent manner.

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Conflict of interest statement

Conflict of Interest

No conflicts of interests are declared by any of the authors.

Figures

Figure 1
Figure 1. A model for proteasome inhibitor-induced increase of the MLL-AF4 level and induction of PAX5-dependent transcription of p27 in pro-B MLL-AF4 leukemia cells
The proteins are not drawn to scale, nor is the protein complex precisely stoichiometric as shown.
See this image and copyright information in PMC

Comment on

References

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