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. 1989:19:267-70.

Prostacyclin, endothelium-derived relaxing factor and vasodilatation

G Siegel  1 , F Schnalke, G Stock, J Grote
Affiliations
  • PMID: 2473608

Prostacyclin, endothelium-derived relaxing factor and vasodilatation

G Siegel et al. Adv Prostaglandin Thromboxane Leukot Res. 1989.

Abstract

In arterial smooth muscle with normal tone or predepolarized and precontracted by noradrenaline, prostacyclin (10(-9) to 10(-6) M) effects a dose-dependent hyperpolarization and relaxation. The hyperpolarization is due to K+ channel opening. In hypoxic vasodilatation, which is likewise induced by membrane hyperpolarization, a share of 20% falls to prostacyclin and 80% to an endothelium derived hyperpolarizing factor.

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