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Randomized Controlled Trial
. 2014 Nov;21(11):1197-203.
doi: 10.1097/GME.0000000000000238.

Vitamin D levels and menopause-related symptoms

Erin S LeBlanc  1 , Manisha Desai, Nancy Perrin, Jean Wactawski-Wende, JoAnn E Manson, Jane A Cauley, Yvonne L Michael, Jean Tang, Catherine Womack, Yiqing Song, Karen C Johnson, Mary J O'Sullivan, Nancy Woods, Marcia L Stefanick
Affiliations
Randomized Controlled Trial

Vitamin D levels and menopause-related symptoms

Erin S LeBlanc et al. Menopause. 2014 Nov.

Abstract

Objective: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women.

Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses.

Results: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's > 0.10 for fully adjusted models).

Conclusions: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.

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Conflict of interest statement

Conflicts of Interest: Dr. Manson and colleagues at Harvard Medical School receive NIH funding for the VITamin D and Omega-3 Trial (Vital). For the remaining authors none were declared.

Figures

Figure 1
Figure 1
Flow of WHI participants into study cohort
See this image and copyright information in PMC

Comment in

  • Letters to the Editor.
    Kim TH, Lee HH, Kim JM. Kim TH, et al. Menopause. 2015 Jul;22(7):797. doi: 10.1097/GME.0000000000000478. Menopause. 2015. PMID: 25988800 No abstract available.

References

    1. Simon JA, Reape KZ. Understanding the menopausal experiences of professional women. Menopause. 2009 Jan;16(1):73–6. - PubMed
    1. McKinlay SM, Brambilla DJ, Posner JG. The normal menopause transition. Maturitas. 1992 Jan;14(2):103–15. - PubMed
    1. Dennerstein L, Dudley EC, Hopper JL, Guthrie JR, Burger HG. A prospective population-based study of menopausal symptoms. Obstet Gynecol. 2000 Sep;96(3):351–8. - PubMed
    1. Li C, Wilawan K, Samsioe G, Lidfeldt J, Agardh CD, Nerbrand C. Health profile of middle-aged women: The Women’s Health in the Lund Area (WHILA) study. Hum Reprod. 2002 May;17(5):1379–85. - PubMed
    1. Groeneveld FP, Bareman FP, Barentsen R, Dokter HJ, Drogendijk AC, Hoes AW. Vasomotor symptoms and well-being in the climacteric years. Maturitas. 1996 Apr;23(3):293–9. - PubMed

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