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. 1989 Apr;27(1-2):62-4.
doi: 10.1007/BF02222199.

Active sensitization does not increase the responsivity of rat peritoneal mast cells to diverse chemical stimuli

P T Peachell  1 , F L Pearce
Affiliations

Active sensitization does not increase the responsivity of rat peritoneal mast cells to diverse chemical stimuli

P T Peachell et al. Agents Actions. 1989 Apr.

Abstract

Peritoneal mast cells from specific pathogen-free rats that had been sensitized to the nematode Nippostrongylus brasiliensis released histamine in a dose-dependent fashion on challenge with antigen, anti-rat IgE, anti-rat IgG and concanavalin A. Cells from non-sensitized animals showed weak or insignificant responses to these agents. However, the two preparations did not obviously differ in their reactivity to a range of pharmacological agents including ATP, dextran, polyamines and calcium ionophores. Both populations were refractory to cholinergic stimulation. These results show that active sensitization does not per se lead to a global increase in mast cell reactivity or releasability.

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References

    1. Immunology. 1982 Jun;46(2):353-9 - PubMed
    1. J Immunol. 1975 Oct;115(4):1078-83 - PubMed
    1. Agents Actions. 1980 Apr;10(1 Pt 2):131-7 - PubMed
    1. Monogr Allergy. 1979;14:288-92 - PubMed
    1. Int Arch Allergy Appl Immunol. 1981;66 Suppl 1:137-9 - PubMed

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