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Meta-Analysis
. 2014 Apr 15;9(4):e93937.
doi: 10.1371/journal.pone.0093937. eCollection 2014.

Association of XPC polymorphisms and lung cancer risk: a meta-analysis

Bo Jin  1 , Yu Dong  1 , Xueyan Zhang  1 , Huimin Wang  1 , Baohui Han  1
Affiliations
Meta-Analysis

Association of XPC polymorphisms and lung cancer risk: a meta-analysis

Bo Jin et al. PLoS One. .

Abstract

Background: Xeroderma pigmentosum complementation group C gene (XPC) is a key member of nucleotide excision repair pathway and plays an important role in human DNA repair system. It is reported that several common polymorphisms of XPC are associated with susceptibility to lung cancer. However, the conclusion is still elusive.

Method: This meta-analysis was performed to determine the relationship between XPC polymorphisms (Lys939Gln, Ala499Val, and PAT) and lung cancer risk. Published literatures were identified by searching online databases and reference lists of relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias were detected by Egger's and Begg's test.

Result: After strict screening, we identified 14 eligible studies in this meta-analysis, including 5647 lung cancer cases and 6908 controls. By pooling all eligible studies, we found that the homozygote Gln939Gln genotype was associated with a significantly increased risk of lung cancer in Asian population (GlnGln vs LysLys, OR=1.229, 95% CI: 1.000-1.510; GlnGln vs LysLys/LysGln, OR=1.257, 95% CI: 1.038-1.522). As for the PAT polymorphism, in Caucasian population, we found carriers of the -/- genotype were associated significantly reduced risk of lung cancer in homozygote comparison model (-/- vs +/+, OR=0.735, 95% CI: 0.567-0.952).

Conclusion: In this meta-analysis we found that Gln939Gln genotype was associated with significantly increased risk of lung cancer in Asian population; the PAT -/- genotype significantly reduced susceptibility to lung cancer in Caucasian population; while the XPC Ala499Val polymorphism was not associated with lung cancer risk.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow Diagram of study selection.
*the two populations in Chang JS’s study were treated as 2 separate studies.
Figure 2
Figure 2. Forrest plot of XPC Lys939Gln polymorphism (GlnGln vs. LysLys/LysGln) by ethnicity.
Figure 3
Figure 3. Forrest plot of XPC Ala499Val polymorphism (AlaVal/ValVal vs. AlaAla).
Figure 4
Figure 4. Forrest plot of XPC PAT polymorphism (−/− vs. +/+) by ethnicity.
See this image and copyright information in PMC

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