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. 1989 May;33(5):641-5.
doi: 10.1128/AAC.33.5.641.

Effect of peptide AS-48 on Enterococcus faecalis subsp. liquefaciens S-47

A Galvez  1 , E Valdivia, M Martinez, M Maqueda
Affiliations

Effect of peptide AS-48 on Enterococcus faecalis subsp. liquefaciens S-47

A Galvez et al. Antimicrob Agents Chemother. 1989 May.

Abstract

The enterococcal peptide AS-48 exerts a concentration-dependent bactericidal effect on Enterococcus faecalis subsp. liquefaciens S-47; cell rescue by cardiolipin and trypsin can be effected only in the first few minutes after antibiotic addition. Gramicidin-exposed cells are protected from killing by AS-48. Long-term and pulse incorporation of radiolabeled substrates into trichloroacetic acid-precipitable material, O2 consumption, and the ability to maintain intracellular potassium levels are impaired shortly after addition of AS-48.

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References

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