doi: 10.1002/chem.201400001.
Epub 2014 Apr 15.
A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy
Affiliations
- PMID: 24737172
- DOI: 10.1002/chem.201400001
Item in Clipboard
A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy
Chemistry.
.
Abstract
A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer.
Keywords: glutathione; photodynamic therapy; photosensitizers; phthalocyanines; singlet oxygen.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Similar articles
-
Disulfide-Linked Dendritic Oligomeric Phthalocyanines as Glutathione-Responsive Photosensitizers for Photodynamic Therapy.Chemistry. 2018 Apr 17;24(22):5779-5789. doi: 10.1002/chem.201706128. Epub 2018 Mar 2. Chemistry. 2018. PMID: 29356199
-
A Biotinylated and Endoplasmic Reticulum-Targeted Glutathione-Responsive Zinc(II) Phthalocyanine for Targeted Photodynamic Therapy.Chem Asian J. 2018 Nov 16;13(22):3509-3517. doi: 10.1002/asia.201800852. Epub 2018 Aug 13. Chem Asian J. 2018. PMID: 29956487
-
An acid-cleavable phthalocyanine tetramer as an activatable photosensitiser for photodynamic therapy.Dalton Trans. 2016 Aug 16;45(33):13021-4. doi: 10.1039/c6dt02283a. Dalton Trans. 2016. PMID: 27396392
-
Pharmaceutical development, composition and quantitative analysis of phthalocyanine as the photosensitizer for cancer photodynamic therapy.J Pharm Biomed Anal. 2014 Jan;87:98-104. doi: 10.1016/j.jpba.2013.05.014. Epub 2013 May 18. J Pharm Biomed Anal. 2014. PMID: 23746989 Review.
-
Recent Advances in Activatable Organic Photosensitizers for Specific Photodynamic Therapy.Chempluschem. 2020 May;85(5):948-957. doi: 10.1002/cplu.202000203. Chempluschem. 2020. PMID: 32401421 Review.
Cited by
-
Bioorthogonal Turn-On BODIPY-Peptide Photosensitizers for Tailored Photodynamic Therapy.Chemistry. 2020 Aug 6;26(44):10014-10023. doi: 10.1002/chem.202001718. Epub 2020 Jul 23. Chemistry. 2020. PMID: 32638402 Free PMC article.
-
Enhancing Precision in Photodynamic Therapy: Innovations in Light-Driven and Bioorthogonal Activation.Pharmaceutics. 2024 Mar 31;16(4):479. doi: 10.3390/pharmaceutics16040479. Pharmaceutics. 2024. PMID: 38675140 Free PMC article. Review.
-
Activatable Photosensitizers: From Fundamental Principles to Advanced Designs.Angew Chem Int Ed Engl. 2025 Apr 7;64(15):e202423348. doi: 10.1002/anie.202423348. Epub 2025 Feb 21. Angew Chem Int Ed Engl. 2025. PMID: 39899458 Free PMC article. Review.
-
Recent applications of phthalocyanines and naphthalocyanines for imaging and therapy.Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017 Jan;9(1):10.1002/wnan.1420. doi: 10.1002/wnan.1420. Epub 2016 Jul 20. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2017. PMID: 27439671 Free PMC article. Review.
-
Cancer-Associated, Stimuli-Driven, Turn on Theranostics for Multimodality Imaging and Therapy.Adv Mater. 2017 Jun;29(23):10.1002/adma.201606857. doi: 10.1002/adma.201606857. Epub 2017 Mar 29. Adv Mater. 2017. PMID: 28370546 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
