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. 2014 May 19;20(21):6241-5.
doi: 10.1002/chem.201400001. Epub 2014 Apr 15.

A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy

Hui He  1 , Pui-Chi Lo, Dennis K P Ng
Affiliations

A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy

Hui He et al. Chemistry. .

Abstract

A zinc(II) phthalocyanine substituted with a 2,4-dinitrobenzenesulfonate group has been prepared. Its fluorescence emission and reactive oxygen species generation can be greatly enhanced by glutathione in phosphate-buffered saline and inside MCF-7 cells. This compound thus functions as a highly efficient molecular-based activatable photosensitizer.

Keywords: glutathione; photodynamic therapy; photosensitizers; phthalocyanines; singlet oxygen.

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