[Recombinant plasmids containing hybrid protein genes with antigenic determinants of the foot and mouth virus]
[Article in
Russian]
- PMID: 2473757
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[Recombinant plasmids containing hybrid protein genes with antigenic determinants of the foot and mouth virus]
[Article in
Russian]
Bioorg Khim.
1989 Apr.
Abstract
Plasmids have been constructed which contain genes coding for fused proteins including beta-galactosidase or human leukocyte interferon alpha 2 and monomeric or pentameric form of the main antigenic determinant of the foot-and-mouth disease virus (FMDV) serotype 01K. Expression of the hybrid genes has been studied. It is shown that fused proteins, containing beta-galactosidase and the antigenic determinant (monomer or pentamer), interact specifically with anti-FMDV anti-sera and with antibodies against peptide 141-160 of FMDV VP1 coat protein.
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