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. 1989 Apr;15(4):508-13.

[Recombinant plasmids containing hybrid protein genes with antigenic determinants of the foot and mouth virus]

[Article in Russian]
E A Chernen'kaia, A I Gurevich, V G Korobko
  • PMID: 2473757

[Recombinant plasmids containing hybrid protein genes with antigenic determinants of the foot and mouth virus]

[Article in Russian]
E A Chernen'kaia et al. Bioorg Khim. 1989 Apr.

Abstract

Plasmids have been constructed which contain genes coding for fused proteins including beta-galactosidase or human leukocyte interferon alpha 2 and monomeric or pentameric form of the main antigenic determinant of the foot-and-mouth disease virus (FMDV) serotype 01K. Expression of the hybrid genes has been studied. It is shown that fused proteins, containing beta-galactosidase and the antigenic determinant (monomer or pentamer), interact specifically with anti-FMDV anti-sera and with antibodies against peptide 141-160 of FMDV VP1 coat protein.

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