[Proto-oncogene expression in the organs of intact adult rats]

Abstract

The study is concerned with the expression of src, sis, fos, myc, Ha-ras, Ki-ras, N-ras, mos, and abl proto-oncogenes in the brain, heart, liver, kidneys, lung, stomach, cross-striated muscle cells and in leukocytes. Some of these genes are shown to be actively transcribed in adult intact rats. Their expression depends on the tissue specificity. Most of the investigated proto-oncogenes are expressed in the liver and kidney weakly, and in the brain and heart--more strongly. A correlation is observed between fos and Ha-ras proto-oncogenes' expression in organs of intact rats.