Comparative Study
doi: 10.1016/0014-5793(89)81429-2.
Caldesmon150, caldesmon77 and skeletal muscle troponin T share a common antigenic determinant
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- PMID: 2473927
- DOI: 10.1016/0014-5793(89)81429-2
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Comparative Study
Caldesmon150, caldesmon77 and skeletal muscle troponin T share a common antigenic determinant
FEBS Lett.
.
Free article
Abstract
Caldesmon and troponin are known to control actin-myosin interaction in smooth and striated muscle. We showed that polyclonal antibodies to smooth muscle caldesmon150 cross-react with non-muscle caldesmon77 and with skeletal muscle troponin T. The epitope recognized by caldesmon antibodies is located in the CB 2 peptide [residues 71-151] of troponin T. It is supposed that the observed cross-reactivity is due to the common structure of the tropomyosin-binding site of caldesmon and troponin T.
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