Neuroinflammation: Contemporary anti-inflammatory treatment approaches

Abstract

We investigated the idea of possible anti-inflammatory treatment approaches for inflammatory disorders in the CNS. The articles used for this review were searched through PubMed, PsycINFO, and Google scholar and published between January 2000 and July 2013. The CNS has its own type of defensive mechanism. The crosstalk between neurons and the immune system take place via small molecules called cytokines that are secreted from glial cells. Previous study suggested that the imbalance of cytokines facilitates the development of CNS disorders. For instance, the interleukin-6 level is raised in the astrocyte cell during depressive episodes, while axons are damaged by the activated lymphocytes and microglia in multiple sclerosis. Several studies demonstrated that cytokines and inflammatory compounds are closely linked to neuropsychiatric and neurodegenerative disorders. Here, we have accumulated and summarized evidence from those papers that support the anti-inflammatory treatment options for inflammatory CNS disorders.