Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2014 Apr 29;111(17):6120-1.
doi: 10.1073/pnas.1404414111. Epub 2014 Apr 16.

Induction of multiciliated cells from induced pluripotent stem cells

Brigitte N Gomperts  1
Affiliations
Comment

Induction of multiciliated cells from induced pluripotent stem cells

Brigitte N Gomperts. Proc Natl Acad Sci U S A. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The author declares no conflict of interest.

Figures

Fig. 1.
Fig. 1.
(i–vi) Schematic of published protocols (–8) for directed differentiation to lung epithelium iPSCs and ESCs in vitro. ActA, Activin A; DSM, Dorsomorphin; PL, progenitor lung.
See this image and copyright information in PMC

Comment on

References

    1. Nishikawa S, Goldstein RA, Nierras CR. The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol. 2008;9(9):725–729. - PubMed
    1. Morrisey EE, Hogan BL. Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell. 2010;18(1):8–23. - PMC - PubMed
    1. Firth AL, et al. Generation of multiciliated cells in functional airway epithelia from human induced pluripotent stem cells. Proc Natl Acad Sci USA. 2014;111:E1723–E1730. - PMC - PubMed
    1. Green MD, et al. Generation of anterior foregut endoderm from human embryonic and induced pluripotent stem cells. Nat Biotechnol. 2011;29(3):267–272. - PMC - PubMed
    1. Longmire TA, et al. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell. 2012;10(4):398–411. - PMC - PubMed