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Case Reports
. 2014 Mar-Apr;46(2):232-3.
doi: 10.4103/0253-7613.129332.

Acute generalized exanthematous pustulosis induced by piroxicam: a case report

Affiliations
Case Reports

Acute generalized exanthematous pustulosis induced by piroxicam: a case report

Y Cherif et al. Indian J Pharmacol. 2014 Mar-Apr.

Abstract

Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction characterized by an acute episode of sterile pustules over erythematous-edematous skin. The main triggering drugs are antibiotics, mainly beta-lactam and macrolides. Non-steroid anti-inflammatory drugs may rarely be responsible. We describe a case of a woman with AGEP, who presented with generalized pustulosis lesions after the use of piroxicam for renal colic. The diagnosis was confirmed by the clinical and histological correlations and the dermatosis resolved after withdrawal of the drug.

Keywords: Acute generalized exanthematous pustulosis; adverse drug reactions; piroxicam; pustulosis.

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Conflict of interest statement

Conflict of Interest: No

Figures

Figure 1
Figure 1
Multiple papules and pustules that coalesced to larger and scaly plaques

References

    1. Turk BG, Gunaydin A, Ertam I, Ozturk G. Adverse cutaneous drug reactions among hospitalized patients: Five year surveillance. Cutan Ocul Toxicol. 2013;32:41–5. - PubMed
    1. Wedi B. Definitions and mechanisms of drug hypersensitivity. Expert Rev Clin Pharmacol. 2010;3:539–51. - PubMed
    1. Sidoroff A, Halevy S, Bavinck JN, Vaillant L, Roujeau JC. Acute generalized exanthematous pustulosis (AGEP) – A clinical reaction pattern. J Cutan Pathol. 2001;28:113–9. - PubMed
    1. Haro-Gabaldón V, Sánchez-Sánchez-Vizcaino J, Ruiz-Avila P, Gutiérrez-Fernández J, Linares J, Naranjo-Sintes R. Acute generalized exanthematous pustulosis with cytomegalovirus infection. Int J Dermatol. 1996;35:735–7. - PubMed
    1. Calistru AM, Lisboa C, Cunha AP, Bettencourt H, Azevedo F. Acute generalized exanthematous pustulosis to amoxicillin associated with parvovirus B19 reactivation. Cutan Ocul Toxicol. 2012;31:258–61. - PubMed

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