Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Apr;6(2):69-80.
doi: 10.4103/0975-7406.129170.

A review exploring biological activities of hydrazones

Affiliations
Review

A review exploring biological activities of hydrazones

Garima Verma et al. J Pharm Bioallied Sci. 2014 Apr.

Abstract

The development of novel compounds, hydrazones has shown that they possess a wide variety of biological activities viz. antimicrobial, anticonvulsant, antidepressant, anti-inflammatory, analgesic, antiplatelet, antimalarial, anticancer, antifungal, antitubercular, antiviral, cardio protective etc., Hydrazones/azomethines/imines possess-NHN = CH- and constitute an important class of compounds for new drug development. A number of researchers have synthesized and evaluated the biological activities of hydrazones. This review aims at highlighting the diverse biological activities of hydrazones.

Keywords: Azomethine; biological activity; hydrazones.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Structure of hydrazones reported as antimicrobial agents
Figure 2
Figure 2
Structure of hydrazones reported as analgesic and anti-inflammatory agents
Figure 3
Figure 3
Structure of hydrazones reported as anticancer agents
Figure 4
Figure 4
Structure of hydrazones reported as CNS agents
Figure 5
Figure 5
Structure of hydrazones reported as antiprotozoal agents
Figure 6
Figure 6
Structure of hydrazones reported as cardioprotective and antiplatelet agents

References

    1. Uppal G, Bala S, Kamboj S, Saini M. Therapeutic review exploring antimicrobial potential of hydrazones as promising lead. Der Pharma Chem. 2011;3:250–68.
    1. Rollas S, Küçükgüzel SG. Biological activities of hydrazone derivatives. Molecules. 2007;12:1910–39. - PMC - PubMed
    1. Narang R, Narasimhan B, Sharma S. A review on biological activities and chemical synthesis of hydrazide derivatives. Curr Med Chem. 2012;19:569–612. - PubMed
    1. Negi VJ, Sharma AK, Negi JS, Ra V. Biological activities of hydrazone derivatives in the new millennium. Int J Pharm Chem. 2012;4:100–9.
    1. Corey EJ, Enders D. Applications of N, N-dimethylhydrazones to synthesis. Use in efficient, positionally and stereochemically selective C=C bond formation, oxidative hydrolysis of carbonyl compounds. Tetrahedron Lett. 1976;17:3–6.