Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 Apr;6(2):127-31.
doi: 10.4103/0975-7406.129178.

Platelet rich fibrin and alloplast in the treatment of intrabony defect

Saurav Panda  1 , Surendar Ramamoorthi  2 , N D Jayakumar  1 , M Sankari  1 , Sheeja S Varghese  1
Affiliations
Case Reports

Platelet rich fibrin and alloplast in the treatment of intrabony defect

Saurav Panda et al. J Pharm Bioallied Sci. 2014 Apr.

Abstract

Periodontal regeneration is defined as the reproduction or reconstitution of a lost or injured part to restore the architecture and function of the periodontium. The ultimate goal of periodontal therapy is to regenerate the lost periodontal tissues caused by periodontitis. The most positive outcome of periodontal regenerative procedures in intra bony defect has been achieved with bone grafts. For complete regeneration, delivery of growth factors in a local environment holds a great deal in adjunct to bone grafts. Platelet rich fibrin (PRF) is considered as second generation platelet concentrate, consisting of viable platelets, releasing various growth factors. Hence, this case report aims to investigate the clinical and radiological (bone fill) effectiveness of autologous PRF along with the use of alloplastic bone mineral in the treatment of intra bony defects.

Keywords: Alloplast; chronic periodontitis; intra bony defects; platelet rich fibrin.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Pre-operative radiograph
Figure 2
Figure 2
Pre-operative view
Figure 3
Figure 3
Platelet rich fibrin mixed with alloplast
Figure 4
Figure 4
Intra-operative view
Figure 5
Figure 5
Platelet rich fibrin with alloplast condensed in place
Figure 6
Figure 6
Adaptation of guided tissue regeneration barrier membrane
Figure 7
Figure 7
Flap approximated and sutures placement
Figure 8
Figure 8
Post-operative radiographs after 6 months
See this image and copyright information in PMC

References

    1. Giannobile WV. The potential role of growth and differentiation factors in periodontal regeneration. J Periodontol. 1996;67:545–53. - PubMed
    1. Froum SJ, Gomez C, Breault MR. Current concepts of periodontal regeneration. A review of the literature. N Y State Dent J. 2002;68:14–22. - PubMed
    1. Trombelli L. Which reconstructive procedures are effective for treating the periodontal intraosseous defect? Periodontol 2000. 2005;37:88–105. - PubMed
    1. Bartold PM, Shi S, Gronthos S. Stem cells and periodontal regeneration. Periodontol 2000. 2006;40:164–72. - PubMed
    1. McClain PK, Schallhorn RG. Long-term assessment of combined osseous composite grafting, root conditioning, and guided tissue regeneration. Int J Periodontics Restorative Dent. 1993;13:9–27. - PubMed

Publication types