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Case Reports
. 2014 Mar 15:14:ic6.
eCollection 2014.

Toxic epidermal necrolysis

Saami Khalifian  1 , Zuhaib Ibrahim  1 , Mohammed T Lilo  2 , Stephen M Milner  1
Affiliations
Case Reports

Toxic epidermal necrolysis

Saami Khalifian et al. Eplasty. .
No abstract available

Keywords: Lyell's syndrome; TEN; drug reaction; stevens-johnson syndrome; toxic epidermal necrolysis.

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Figures

Figure 1
Figure 1
Generalized epidermolysis on anterior and posterior torso with crusty erosions on oral mucosa.
Figure 2
Figure 2
Characteristic histopathologic changes in toxic epidermal necrolysis. (a) There is a broad, paucicellular, subepidermal blister with confluent, full-thickness necrosis of the blister roof. At the edge of the blister, there is prominent dyskeratosis and vacuolar alteration of the epidermal basal layer (hematoxylin and eosin, original magnification 100X). (b) There is an unaltered, basket weave stratum corneum and a relative absence of inflammation (hematoxylin and eosin, original magnification 400X).
See this image and copyright information in PMC

References

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    1. Roujeau JC. Drug-induced toxic epidermal necrolysis. II. Current aspects. Clin Dermatol. 1993;11(4):493–500. - PubMed
    1. Roujeau JC, Kelly JP, Naldi L, et al. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med. 1995;333(24):1600–7. - PubMed
    1. Becker DS. Toxic epidermal necrolysis. Lancet. 1998;351(9113):1417–20. - PubMed
    1. McGee T, Munster A. Toxic epidermal necrolysis syndrome: mortality rate reduced with early referral to regional burn center. Plast Reconstr Surg. 1998;102(4):1018–22. - PubMed

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