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Case Reports
. 2014 Mar 24:3:158.
doi: 10.1186/2193-1801-3-158. eCollection 2014.

Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report

Roberto Bassi  1 , Andrea Vergani  2 , Francesca D'Addio  3 , Moufida Ben Nasr  2 , Alessio Mocci  4 , Maria Pia Rastaldi  5 , Takaharu Ichimura  6 , Joseph Vincent Bonventre  6 , Paolo Fiorina  7
Affiliations
Case Reports

Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: a preliminary report

Roberto Bassi et al. Springerplus. .

Abstract

Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.

Keywords: Inflammation; Ischemia/reperfusion; Kidney disease; Kidney transplantation; Radical oxygen species.

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Figures

Figure 1
Figure 1
IAC treatment partially prevented serum creatinine levels increase, body weight loss and acute tubular necrosis after I/R induction. (A) Untreated control (CTRL) mice showed at day (D) 1 and D2 a more significant increase in serum creatinine levels after the induction of ischemia/reperfusion compared to non-peptidyl low molecular weight radical scavenger (IAC)-treated mice (D1 and D2: CTRL vs. IAC-treated, *p < 0.05). (B) Untreated CTRL mice showed a progressive and more evident reduction of body weight after ischemia/reperfusion induction compared to IAC-treated mice (D1, D2 and D4: CTRL vs. IAC-treated, *p < 0.05). (C) Untreated CTRL mice showed acute tubular necrosis signs in kidneys outer medulla with hyaline and granular casts accumulation. (D) Conversely, the extent of acute tubular necrosis was reduced in IAC-treated mice.
See this image and copyright information in PMC

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