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. 2014 Mar;18(2):213-6.
doi: 10.4103/2230-8210.129114.

Congenital hypothyroidism in neonates

Aneela Anjum  1 , Muhammad Faheem Afzal  1 , Syed Muhammad Javed Iqbal  1 , Muhammad Ashraf Sultan  1 , Asif Hanif  2
Affiliations

Congenital hypothyroidism in neonates

Aneela Anjum et al. Indian J Endocrinol Metab. 2014 Mar.

Abstract

Context: Congenital hypothyroidism (CH) is one of the most common preventable causes of mental retardation in children and it occurs in approximately 1:2,000-1:4,000 newborns.

Aims and objectives: The aim of this study is to determine the frequency of CH in neonates.

Settings and design: This cross-sectional study was conducted in neonatal units of the Department of Pediatrics Unit-I, King Edward Medical University/Mayo Hospital, Lahore and Lady Willington Hospital Lahore in 6 months (January-June 2011).

Materials and methods: Sample was collected by non-probability purposive sampling. After consent, 550 newborn were registered for the study. Demographic data and relevant history was recorded. After aseptic measures, 2-3 ml venous blood analyzed for thyroid-stimulating hormone (TSH) level by immunoradiometric assay. Treatment was started according to the individual merit as per protocol.

Statistical analysis used: Data was analyzed by SPSS 17 and Chi-square test was applied to find out the association of CH with different variables.

Results: The study population consisted of 550 newborns. Among 550 newborns, 4 (0.8%) newborns had elevated TSH level. CH had statistically significant association with mother's hypothyroidism (P value 0.000) and mother's drug intake during the pregnancy period (P value 0.013).

Conclusion: CH is 0.8% in neonates. It has statistically significant association with mother's hypothyroidism and mother's drug intake during pregnancy.

Keywords: Congenital hypothyroidism; newborn; thyroid-stimulating hormone.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Distribution of cases by thyroid-stimulating hormone level (n=550)
See this image and copyright information in PMC

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