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. 2014 Mar;6(3):133-8.
doi: 10.4103/1947-2714.128475.

Ovarian granulosa cell tumor: clinical features, treatment, outcome, and prognostic factors

Divya Khosla  1 , Kislay Dimri  1 , Awadhesh K Pandey  1 , Rohit Mahajan  1 , Romeeta Trehan  1
Affiliations

Ovarian granulosa cell tumor: clinical features, treatment, outcome, and prognostic factors

Divya Khosla et al. N Am J Med Sci. 2014 Mar.

Abstract

Background: Granulosa cell tumors are rare neoplasms characterized by long natural history and favorable prognosis.

Aims: The objective of this study was to determine the clinical presentation, treatment, outcome, and prognostic factors for patients of granulosa cell tumors.

Materials and methods: A retrospective analysis of 26 patients of granulosa cell tumor of ovary from 2002 to 2011 was carried out. The records of all patients were analyzed to determine clinical presentation, treatment, survival, and prognostic factors.

Results: The median age of the patients was 50 years (range, 17-71 years). Abdominal pain was the most common presenting symptom. The median follow-up was 71.4 months (range, 21.6-149.9 months). The estimated 5 and 10 year overall survival (OS) was 84.6 and 72.5%, respectively. Event-free survival (EFS) was 76.5 and 52.9% at 5 and 10 years, respectively. Advanced stage was significant independent poor prognostic indicator for both OS and EFS.

Conclusion: Majority of the patients with granulosa cell tumors of the ovary present in early stage. Surgery is the primary treatment modality for granulosa cell tumors. Advanced stage and presence of residual disease were associated with inferior survival, but only prospective studies can ascertain their definite role.

Keywords: Granulosa cell tumor; Ovary; Prognosis; Survival; Treatment.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Kaplan-Meier curve showing comparison of overall survival between localized and advanced stage
Figure 2
Figure 2
Kaplan-Meier curve comparing overall survival for patients with presence or absence of residual disease
See this image and copyright information in PMC

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