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. 2014:2014:469278.
doi: 10.1155/2014/469278. Epub 2014 Mar 12.

Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy

Michael Schneider  1 , Anne Engel  1 , Peter A Fasching  1 , Lothar Häberle  1 , Elisabeth B Binder  2 , Franziska Voigt  3 , Jennifer Grimm  4 , Florian Faschingbauer  1 , Anna Eichler  4 , Ulf Dammer  1 , Dirk Rebhan  1 , Manuela Amann  1 , Eva Raabe  1 , Tamme W Goecke  3 , Carina Quast  2 , Matthias W Beckmann  1 , Johannes Kornhuber  5 , Anna Seifert  2 , Stefanie Burghaus  1
Affiliations

Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy

Michael Schneider et al. Biomed Res Int. 2014.

Abstract

Purpose: The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in genes of the stress hormone signaling pathway, specifically FKBP5, NR3C1, and CRHR1, are associated with depressive symptoms during and after pregnancy.

Methods: The Franconian Maternal Health Evaluation Study (FRAMES) recruited healthy pregnant women prospectively for the assessment of maternal and fetal health including the assessment of depressiveness. The German version of the 10-item Edinburgh Postnatal Depression Scale (EPDS) was completed at three time points in this prospective cohort study. Visit 1 was at study entry in the third trimester of the pregnancy, visit 2 was shortly after birth, and visit 3 was 6-8 months after birth. Germline DNA was collected from 361 pregnant women. Nine SNPs in the above mentioned genes were genotyped. After construction of haplotypes for each gene, a multifactorial linear mixed model was performed to analyse the depression values over time.

Results: EPDS values were within expected ranges and comparable to previously published studies. Neither did the depression scores differ for comparisons among haplotypes at fixed time points nor did the change over time differ among haplotypes for the examined genes. No haplotype showed significant associations with depressive symptoms severity during pregnancy or the postpartum period.

Conclusion: The analysed candidate haplotypes in FKBP5, NR3C1, and CRHR1 did not show an association with depression scores as assessed by EPDS in this cohort of healthy unselected pregnant women.

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Figures

Figure 1
Figure 1
Mean EPDS values of FKBP5 haplotype CGTC with 95% confidence intervals.
Figure 2
Figure 2
Mean EPDS values of GRNR3C1 haplotype GAT with 95% confidence intervals.
Figure 3
Figure 3
Mean EPDS values of CRHR1 haplotype CC with 95% confidence intervals.
See this image and copyright information in PMC

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