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Review
. 2014:2014:476068.
doi: 10.1155/2014/476068. Epub 2014 Mar 25.

Porphyromonas gingivalis: major periodontopathic pathogen overview

Jaroslav Mysak  1 , Stepan Podzimek  1 , Pavla Sommerova  1 , Yelena Lyuya-Mi  1 , Jirina Bartova  1 , Tatjana Janatova  1 , Jarmila Prochazkova  1 , Jana Duskova  1
Affiliations
Review

Porphyromonas gingivalis: major periodontopathic pathogen overview

Jaroslav Mysak et al. J Immunol Res. 2014.

Abstract

Porphyromonas gingivalis is a Gram-negative oral anaerobe that is involved in the pathogenesis of periodontitis and is a member of more than 500 bacterial species that live in the oral cavity. This anaerobic bacterium is a natural member of the oral microbiome, yet it can become highly destructive (termed pathobiont) and proliferate to high cell numbers in periodontal lesions: this is attributed to its arsenal of specialized virulence factors. The purpose of this review is to provide an overview of one of the main periodontal pathogens-Porphyromonas gingivalis. This bacterium, along with Treponema denticola and Tannerella forsythia, constitute the "red complex," a prototype polybacterial pathogenic consortium in periodontitis. This review outlines Porphyromonas gingivalis structure, its metabolism, its ability to colonize the epithelial cells, and its influence upon the host immunity.

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