Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2014 Aug;8(4):381-3.
doi: 10.1586/17476348.2014.908715. Epub 2014 Apr 18.

A turn on and a turn off: BLT1 and BLT2 mechanisms in the lung

Masaki Watanabe  1 , Kentaro Machida, Hiromasa Inoue
Affiliations
Editorial

A turn on and a turn off: BLT1 and BLT2 mechanisms in the lung

Masaki Watanabe et al. Expert Rev Respir Med. 2014 Aug.

Abstract

Leukotriene B4 (LTB4), a potent lipid mediator of inflammation derived from arachidonic acid through the action of 5-lipoxygenase, has been implicated in the pathophysiology of several inflammatory diseases, including asthma and chronic obstructive pulmonary disease. A high-affinity LTB4 receptor BLT1 has been shown to exert proinflammatory roles. A cyclooxygenase metabolite, 12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT), is an endogenous ligand for BLT2, a low-affinity LTB4 receptor. The recent study indicated that BLT2 has a protective role in allergic airway inflammation, suggesting different functions between BLT1 and BLT2 in the pathogenesis of asthma. Selective BLT1 antagonists may have a potential therapeutic application in patients with asthma, and BLT2 may represent a novel therapeutic target for lung diseases.

Keywords: BLT1; BLT2; LTB4; lung disease.

PubMed Disclaimer

Publication types