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Comment
. 2014 Apr 16;82(2):251-3.
doi: 10.1016/j.neuron.2014.04.005.

Muscle matters in Kennedy's disease

Carlo Rinaldi  1 , Laura C Bott  2 , Kenneth H Fischbeck  3
Affiliations
Comment

Muscle matters in Kennedy's disease

Carlo Rinaldi et al. Neuron. .

Abstract

Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortes et al. (2014) in this issue of Neuron and Lieberman et al. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.

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Figures

Figure 1
Figure 1
Reducing mutant AR expression in muscle has beneficial effects in SBMA mouse models.
See this image and copyright information in PMC

Comment on

References

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