Hidden progenitors replace microglia in the adult brain

Ethan G Hughes¹, Dwight E Bergles²

Affiliations

¹ Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
² Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: dbergles@jhmi.edu.

PMID: 24742453
DOI: 10.1016/j.neuron.2014.04.010

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Hidden progenitors replace microglia in the adult brain

Ethan G Hughes et al. Neuron. 2014.

Free article

. 2014 Apr 16;82(2):253-5.

doi: 10.1016/j.neuron.2014.04.010.

Authors

Ethan G Hughes¹, Dwight E Bergles²

Affiliations

¹ Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA.
² Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA. Electronic address: dbergles@jhmi.edu.

PMID: 24742453
DOI: 10.1016/j.neuron.2014.04.010

Abstract

Microglia are highly dynamic components of the innate immune system. In this issue of Neuron, Elmore et al. (2014) report that global depletion of microglia triggers mobilization of latent microglial progenitors throughout the CNS, resulting in rapid repopulation.

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Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.
Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, Rice RA, Kitazawa M, Matusow B, Nguyen H, West BL, Green KN. Elmore MR, et al. Neuron. 2014 Apr 16;82(2):380-97. doi: 10.1016/j.neuron.2014.02.040. Neuron. 2014. PMID: 24742461 Free PMC article.

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Hidden progenitors replace microglia in the adult brain

Affiliations

Hidden progenitors replace microglia in the adult brain

Authors

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Abstract

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