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. 2014 Aug;34(8):629-33.
doi: 10.1038/jp.2014.67. Epub 2014 Apr 17.

Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III

L F Chalak  1 , T L DuPont  1 , P J Sánchez  1 , A Lucke  1 , R J Heyne  1 , M C Morriss  2 , N K Rollins  2
Affiliations

Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III

L F Chalak et al. J Perinatol. 2014 Aug.

Abstract

Objective: Bayley-III scales are currently used to evaluate outcomes of term infants following hypothermia therapy, while all before reported outcomes in this population have used Bayley-II. Our objectives were to determine the incidence of abnormal neurodevelopmental outcomes using Bayley III and the predictive value of Magnetic resonance imaging (MRI) in infants who received systemic hypothermia.

Study design: We conducted a prospective cohort study of inborn infants who underwent hypothermia for moderate/severe neonatal encephalopathy from October 2005-November 2011.

Result: Eighty newborns underwent hypothermia (incidence of 1/1000). Of the survivors, 89% had Bayley-III performed around 24 months of age. An abnormal outcome using Bayley-III <85 occurred in 50%, while Bayley III <70 occurred in 13%. MRI predicted Bayley III<85 with sensitivity of 73%, specificity of 84%, positive-predictive value of 84% and negative-predictive value of 74%.

Conclusion: A Bayley-III 85 cutoff identifies a disability rate of 50%, and MRI was predictive of abnormal outcomes. Findings can be useful for counseling of families and planning of future studies using Bayley III.

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Conflict of interest statement

Conflict of interest: Nothing to declare

Figures

FIGURE 1
FIGURE 1
Flow Chart of Patient Population.
See this image and copyright information in PMC

References

    1. Levene ML, Kornberg J, Williams TH. The incidence and severity of post-asphyxial encephalopathy in full-term infants. Early Hum Dev. 1985 May;11(1):21–6. Epub 1985/05/01.eng. - PubMed
    1. Zhou WH, Cheng GQ, Shao XM, Liu XZ, Shan RB, Zhuang DY, et al. Selective head cooling with mild systemic hypothermia after neonatal hypoxic-ischemic encephalopathy: a multicenter randomized controlled trial in China. J Pediatr. 2010 Sep;157(3):367–72. 72 e1–3. Epub 2010/05/22.eng. - PubMed
    1. Simbruner G, Mittal RA, Rohlmann F, Muche R. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics. 2010 Oct;126(4):e771–8. Epub 2010/09/22.eng. - PubMed
    1. Shankaran S, Laptook AR, Ehrenkranz RA, Tyson JE, McDonald SA, Donovan EF, et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N Engl J Med. 2005 Oct 13;353(15):1574–84. Epub 2005/10/14.eng. - PubMed
    1. Azzopardi D, Brocklehurst P, Edwards D, Halliday H, Levene M, Thoresen M, et al. The TOBY Study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial. BMC Pediatr. 2008;8:17. Epub 2008/05/02.eng. - PMC - PubMed

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