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. 2014 May;10(5):327-8.
doi: 10.1038/nchembio.1504.

Pluripotency: citrullination unravels stem cells

Daniel J Slade  1 , Venkataraman Subramanian  1 , Paul R Thompson  1
Affiliations

Pluripotency: citrullination unravels stem cells

Daniel J Slade et al. Nat Chem Biol. 2014 May.

Abstract

Maintenance of the pluripotent stem cell state is regulated by the post-translational modification of histones. The discovery that citrullination of the linker histone H1 is critical to this process represents a new role for the protein arginine deiminases (PADs) in development.

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Figures

Figure 1
Figure 1
PAD4 is a regulator of pluripotency gene expression through the conversion of arginine to citrulline in histones. Protein arginine deiminase 4 (PAD4) citrullinates core (H3, H4) and linker (H1) histones, leading to chromatin decondensation and the expression of pluripotency markers in embryonic stem-cells, which can be reversed upon inhibition of PAD activity.
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References

    1. Bicker KL, Thompson PR. The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers. 2013;99:155–63. - PMC - PubMed
    1. Kaplan MJ, Radic M. Neutrophil extracellular traps: double-edged swords of innate immunity. J Immunol. 2012;189:2689–95. - PMC - PubMed
    1. Cherrington BD, et al. Potential role for PAD2 in gene regulation in breast cancer cells. PLoS One. 2012;7:e41242. - PMC - PubMed
    1. Cuthbert GL, et al. Histone deimination antagonizes arginine methylation. Cell. 2004;118:545–553. - PubMed
    1. Yao H, et al. Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J Biol Chem. 2008;283:20060–20068. - PMC - PubMed

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