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Comment
. 2014 Jun;24(6):641-2.
doi: 10.1038/cr.2014.51. Epub 2014 Apr 18.

A chemical approach to "rewire" neural progenitor cells

Min-Zu Wu  1 , Mo Li  1 , Guang-Hui Liu  2 , Juan Carlos Izpisua Belmonte  1
Affiliations
Comment

A chemical approach to "rewire" neural progenitor cells

Min-Zu Wu et al. Cell Res. 2014 Jun.

Abstract

Generation of neural progenitor cells (NPCs) from pluripotent stem cells including ESCs and iPSCs and derivation of NPCs from somatic tissues have been considered promising approaches that could be used therapeutically to restore function in patients suffering neurodegenerative diseases. A new study published in Cell Research shows, for the first time, the generation of NPCs from somatic cells by small molecule compounds under hypoxia without exogenous transcription factors.

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