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Review
. 2014 Apr 14;20(14):3960-6.
doi: 10.3748/wjg.v20.i14.3960.

New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer

Lin-Hai Yan  1 , Wei-Yuan Wei  1 , Yu-Bo Xie  1 , Qiang Xiao  1
Affiliations
Review

New insights into the functions and localization of the homeotic gene CDX2 in gastric cancer

Lin-Hai Yan et al. World J Gastroenterol. .

Abstract

Gastric cancer is one of the most frequent cancers, and it ranks the third most common cancer in China. The most recently caudal-related homeobox transcription factor 2 (CDX2) is expressed in a large number of human gastrointestinal cancers. In addition, gastric epithelial cell mutations in CDX2 result in tumor promotion, which is characterized by cellular drug resistance and a high proclivity for developing cancer. A series of publications over the past years suggests a mechanism by which CDX2 overexpression results in multidrug resistance. CDX2 appears to forward control regenerating IV and the multidrug resistance 1 expression signaling pathway for regulation of cell drug resistance.

Keywords: Apoptosis; Caudal-related homeobox transcription factor 2; Drug resistance; Gastric cancer; Intestinal metaplasia.

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