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Case Reports
. 2014 Apr 14;20(14):4102-5.
doi: 10.3748/wjg.v20.i14.4102.

Simultaneous liver mucinous cystic and intraductal papillary mucinous neoplasms of the bile duct: a case report

Agnieszka Budzynska  1 , Marek Hartleb  1 , Ewa Nowakowska-Dulawa  1 , Robert Krol  1 , Piotr Remiszewski  1 , Michal Mazurkiewicz  1
Affiliations
Case Reports

Simultaneous liver mucinous cystic and intraductal papillary mucinous neoplasms of the bile duct: a case report

Agnieszka Budzynska et al. World J Gastroenterol. .

Abstract

Cystic hepatic neoplasms are rare tumors, and are classified into two separate entities: mucinous cystic neoplasms (MCNs) and intraductal papillary mucinous neoplasms of the bile duct (IPMN-B). We report the case of a 56-year-old woman who presented with abdominal pain and jaundice due to the presence of a large hepatic multilocular cystic tumor associated with an intraductal tumor. Partial hepatectomy with resection of extrahepatic bile ducts demonstrated an intrahepatic MCN and an intraductal IPMN-B. This is the first report of the simultaneous occurrence of these two histologically distinct entities in the liver.

Keywords: Intraductal papillary mucinous neoplasm of the bile duct; Liver; Mucinous cystic neoplasm.

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Figures

Figure 1
Figure 1
Computed tomography scan and T1-weighted magnetic resonance imaging. A: Computed tomography scan (portal phase) shows a hepatic cystic tumor with thin contrast-enhanced septum and dilated intrahepatic bile ducts; B: T1-weighted magnetic resonance imaging of the tumor presents a hyperintense, multiseptal cystic lesion that does not communicate with the bile ducts.
Figure 2
Figure 2
Magnetic resonance and preoperative endoscopic retrograde cholangiopancreatography. A: Magnetic resonance cholangiopancreatography shows dilated main hepatic and common bile duct with a sharp change in diameter from 25 to 5 mm; B: Preoperative endoscopic retrograde cholangiopancreatography shows marked dilation of the extrahepatic biliary ducts with a contrast-filling defect caused by an oval intraductal tumor.
Figure 3
Figure 3
Histology of the intrahepatic tumor. A: The cyst is covered with a single layer of cuboidal epithelial cells showing low grade dysplasia (hematoxylin-eosin stain, × 100 magnification); B: The tumor produces mucin; C: Ovarian-like stroma staining positively for estrogen receptor.
Figure 4
Figure 4
Histology of the intraductal papillary mucinous neoplasm of the bile duct showing papillary proliferation.
See this image and copyright information in PMC

References

    1. Tsui WMS, Adsay NV, Crawford JM. Mucinous cystic neoplasms of the liver. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds), editors. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Digestive System. Lyon: IARC Press; 2010. pp. 236–238.
    1. Chen TC, Nakanuma Y, Zen Y, Chen MF, Jan YY, Yeh TS, Chiu CT, Kuo TT, Kamiya J, Oda K, et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology. 2001;34:651–658. - PubMed
    1. Zen Y, Pedica F, Patcha VR, Capelli P, Zamboni G, Casaril A, Quaglia A, Nakanuma Y, Heaton N, Portmann B. Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct. Mod Pathol. 2011;24:1079–1089. - PubMed
    1. Yeh TS, Tseng JH, Chiu CT, Liu NJ, Chen TC, Jan YY, Chen MF. Cholangiographic spectrum of intraductal papillary mucinous neoplasm of the bile ducts. Ann Surg. 2006;244:248–253. - PMC - PubMed
    1. Matsubara T, Sato Y, Sasaki M, Harada K, Nomoto K, Tsuneyama K, Nakamura K, Gabata T, Matsui O, Nakanuma Y. Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts. Hum Pathol. 2012;43:2177–2186. - PubMed

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