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. 2014:2014:565784.
doi: 10.1155/2014/565784. Epub 2014 Mar 13.

Effect of huanglian jiedu decoction on thoracic aorta gene expression in spontaneous hypertensive rats

Gui-Hua Yue  1 , Shao-Yuan Zhuo  1 , Meng Xia  1 , Zhuo Zhang  2 , Yi-Wen Gao  2 , Yuan Luo  2
Affiliations

Effect of huanglian jiedu decoction on thoracic aorta gene expression in spontaneous hypertensive rats

Gui-Hua Yue et al. Evid Based Complement Alternat Med. 2014.

Abstract

Objective. Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension effects of Huanglian Jiedu Decoction (HJD) on thoracic aorta gene expression in spontaneous hypertensive rats. Methods. A rat model of spontaneous hypertension was used. The gene change profile of thoracic aorta after JHD treatment was assessed by GeneChip(GC) analysis using the Agilent Whole Rat Genome Oligo Microarray. Results. Hypertension induced 441 genes upregulated and 417 genes downregulated compared with the normal control group. Treatment of HJD resulted in 76 genes downregulated and 20 genes upregulated. GC data analysis showed that the majority of change genes were involved in immune system process, developmental process, and cell death. Conclusion. Hypertension altered expression of many genes that regulate various biological functions. HJD significantly reduced hypertension and altered the gene expression profiles of SHR rats. These changing genes were involved in many cellular functions such as regulating smooth muscle contraction, Ca(2+) homeostasis, and NO pathway. This study provides the potential novel insights into hypertension and antihypertension effects of HJD.

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Figures

Figure 1
Figure 1
Effects of HJD on blood pressure in rats. BP of rat was measured with mmHg unit. There were 8 rats in each group. *P < 0.05 versus SHR group.
Figure 2
Figure 2
Hypertension induced gene changes compared with normal control rats. Note: model = spontaneous hypertension rats (SHR) model group, and control = normotensive Wistar-Kyoto rats control group.
Figure 3
Figure 3
HJD treatment caused gene changes compared with untreated SHR rats versus SHR. Note: model = spontaneous hypertension rats (SHR) model group; medication = HJD treatment group.
See this image and copyright information in PMC

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